Health Topics
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Publication Date: December 1999
Revised: June 2004
Questions and Answers About Fibromyalgia
Table of Contents
Information Box
What Is Fibromyalgia?
Fibromyalgia syndrome is a common and chronic disorder
characterized by widespread muscle pain, fatigue, and
multiple tender points. The word fibromyalgia comes from
the Latin term for fibrous tissue (fibro) and the Greek ones
for muscle (myo) and pain (algia). Tender points are specific
places on the body—on the neck, shoulders, back, hips, and
upper and lower extremities—where people with
fibromyalgia feel pain in response to slight pressure.
Although fibromyalgia is often considered an arthritisrelated
condition, it is not truly a form of arthritis (a disease
of the joints) because it does not cause inflammation or
damage to the joints, muscles, or other tissues. Like arthritis,
however, fibromyalgia can cause significant pain and fatigue,
and it can interfere with a person's ability to carry on daily
activities. Also like arthritis, fibromyalgia is considered a
rheumatic condition.
You may wonder what exactly rheumatic means. Even
physicians do not always agree on whether a disease is
considered rheumatic. If you look up the word in the
dictionary, you'll find it comes from the Greek word rheum,
which means flux—not an explanation that gives you a
better understanding. In medicine, however, the term
rheumatic means a medical condition that impairs the joints
and/or soft tissues and causes chronic pain.
In addition to pain and fatigue, people who have
fibromyalgia may experience
- sleep disturbances,
- morning stiffness,
- headaches,
- irritable bowel syndrome,
- painful menstrual periods,
- numbness or tingling of the extremities,
- restless legs syndrome,
- temperature sensitivity,
- cognitive and memory problems (sometimes referred to as "fibro fog"), or
- a variety of other symptoms.
Fibromyalgia is a syndrome rather than a disease. Unlike a
disease, which is a medical condition with a specific cause
or causes and recognizable signs and symptoms, a
syndrome is a collection of signs, symptoms, and medical
problems that tend to occur together but are not related to a
specific, identifiable cause.
Who Gets Fibromyalgia?
According to a paper published by the American College of
Rheumatology (ACR), fibromyalgia affects 3 to 6 million - or
as many as one in 50 - Americans. For unknown reasons,
between 80 and 90 percent of those diagnosed with
fibromyalgia are women; however, men and children also can
be affected. Most people are diagnosed during middle age,
although the symptoms often become present earlier in life.
People with certain rheumatic diseases, such as rheumatoid
arthritis, systemic lupus erythematosus (commonly called
lupus), or ankylosing spondylitis (spinal arthritis) may be more
likely to have fibromyalgia, too.
Several studies indicate that women who have a family member
with fibromyalgia are more likely to have fibromyalgia themselves,
but the exact reason for this—whether it be hereditary or caused
by environmental factors or both—is unknown. One study
supported by the National Institute of Arthritis and
Musculoskeletal and Skin Diseases (NIAMS) is trying to identify
if certain genes predispose some people to fibromyalgia. (See
What Are Researchers Learning About Fibromyalgia?)
What Causes Fibromyalgia?
The causes of fibromyalgia are unknown, but there are
probably a number of factors involved. Many people associate
the development of fibromyalgia with a physically or
emotionally stressful or traumatic event, such as an automobile
accident. Some connect it to repetitive injuries. Others link
it to an illness. People with rheumatoid arthritis and other
autoimmune diseases, such as lupus, are particularly likely
to develop fibromyalgia. For others, fibromyalgia seems to
occur spontaneously.
Many researchers are examining other causes, including
problems with how the central nervous system (the brain
and spinal cord) processes pain.
Some scientists speculate that a person's genes may
regulate the way his or her body processes painful stimuli.
According to this theory, people with fibromyalgia may
have a gene or genes that cause them to react strongly to
stimuli that most people would not perceive as painful.
However, those genes—if they, in fact, exist—have not
been identified.
How Is Fibromyalgia Diagnosed?
Research shows that people with fibromyalgia typically see
many doctors before receiving the diagnosis. One reason for
this may be that pain and fatigue, the main symptoms of
fibromyalgia, overlap with many other conditions.
Therefore, doctors often have to rule out other potential
causes of these symptoms before making a diagnosis of
fibromyalgia. Another reason is that there are currently no
diagnostic laboratory tests for fibromyalgia; standard
laboratory tests fail to reveal a physiologic reason for pain.
Because there is no generally accepted, objective test for
fibromyalgia, some doctors unfortunately may conclude a
patient's pain is not real, or they may tell the patient there is
little they can do.
A doctor familiar with fibromyalgia, however, can make a
diagnosis based on two criteria established by the ACR: a
history of widespread pain lasting more than 3 months and
the presence of tender points. Pain is considered to be
widespread when it affects all four quadrants of the body;
that is, you must have pain in both your right and left sides
as well as above and below the waist to be diagnosed with fibromyalgia. The ACR also has designated 18 sites on the body as possible tender points. For a fibromyalgia
diagnosis, a person must have 11 or more tender points.
(See illustration on page 5.) One of these predesignated
sites is considered a true tender point only if the person
feels pain upon the application of 4 kilograms of pressure
to the site. People who have fibromyalgia certainly may
feel pain at other sites, too, but those 18 standard possible
sites on the body are the criteria used for classification.
The location of the nine paired tender points that
comprise the 1990 American College of Rheumatology
criteria for fibromyalgia.
This illustration is copyrighted by the Arthritis Foundation and may not be reproduced without permission.
How Is Fibromyalgia Treated?
Fibromyalgia can be difficult to treat. Not all doctors are
familiar with fibromyalgia and its treatment, so it is
important to find a doctor who is. Many family
physicians, general internists, or rheumatologists (doctors
who specialize in arthritis and other conditions that affect
the joints or soft tissues) can treat fibromyalgia.
Fibromyalgia treatment often requires a team approach,
with your doctor, a physical therapist, possibly other
health professionals, and most importantly, yourself, all
playing an active role. It can be hard to assemble this
team, and you may struggle to find the right professionals
to treat you. When you do, however, the combined
expertise of these various professionals can help you
improve your quality of life.
You may find several members of the treatment team you
need at a clinic. There are pain clinics that specialize in
pain and rheumatology clinics that specialize in arthritis and
other rheumatic diseases, including fibromyalgia.
At present, there are no medications approved by the U.S.
Food and Drug Administration (FDA) for treating
fibromyalgia, although a few such drugs are in development.
Doctors treat fibromyalgia with a variety of medications
developed and approved for other purposes.
Following are some of the most commonly used categories of
drugs for fibromyalgia:
Analgesics
Analgesics are painkillers. They range from over-the-counter
acetaminophen (Tylenol*) to prescription medicines, such as
tramadol (Ultram), and even stronger narcotic preparations.
For a subset of people with fibromyalgia, narcotic
medications are prescribed for severe muscle pain. However,
there is no solid evidence showing that narcotics actually
work to treat the chronic pain of fibromyalgia, and most
doctors hesitate to prescribe them for long-term use because
of the potential that the person taking them will become
physically or psychologically dependent on them.
* Brand names included in this booklet are provided as examples only, and their inclusion does not mean that these products are endorsed by the National Institutes of Health or any other Government agency. Also, if a particular brand name is not mentioned, this does not mean or imply that the product is unsatisfactory.
Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)
As their name implies, nonsteroidal anti-inflammatory
drugs, including aspirin, ibuprofen (Advil, Motrin), and naproxen sodium (Anaprox, Aleve), are used to treat inflammation. Although inflammation is not a symptom of
fibromyalgia, NSAIDs also relieve pain. The drugs work by
inhibiting substances in the body called prostaglandins,
which play a role in pain and inflammation. These
medications, some of which are available without a
prescription, may help ease the muscle aches of fibromyalgia.
They may also relieve menstrual cramps and the headaches
often associated with fibromyalgia.
Antidepressants
Perhaps the most useful medications for fibromyalgia are
several in the antidepressant class. Antidepressants elevate
the levels of certain chemicals in the brain, including
serotonin and norepinephrine (which was formerly called
adrenaline). Low levels of these chemicals are associated not
only with depression, but also with pain and fatigue.
Increasing the levels of these chemicals can reduce pain in
people who have fibromyalgia. Doctors prescribe several
types of antidepressants for people with fibromyalgia,
described below.
-
Tricyclic antidepressants—When taken at bedtime in
dosages lower than those used to treat depression,
tricyclic antidepressants can help promote restorative
sleep in people with fibromyalgia. They also can relax
painful muscles and heighten the effects of the body's
natural pain-killing substances called endorphins.
Tricyclic antidepressants have been around for almost
half a century. Some examples of tricyclic medications
used to treat fibromyalgia include amitriptyline
hydrochloride (Elavil, Endep), cyclobenzaprine
(Cycloflex, Flexeril, Flexiban), doxepin (Adapin,
Sinequan), and nortriptyline (Aventyl, Pamelor). Both
amitriptyline and cyclobenzaprine have been proved
useful for the treatment of fibromyalgia.
-
Selective serotonin reuptake inhibitors—If a tricyclic
antidepressant fails to bring relief, doctors sometimes
prescribe a newer type of antidepressant called a
selective serotonin reuptake inhibitor (SSRI). As with
tricyclics, doctors usually prescribe these for people
with fibromyalgia in lower dosages than are used to
treat depression. By promoting the release of serotonin,
these drugs may reduce fatigue and some other
symptoms associated with fibromyalgia. The group of
SSRIs includes fluoxetine (Prozac), paroxetine (Paxil),
and sertraline (Zoloft).
SSRIs may be prescribed along with a tricyclic
antidepressant. Doctors rarely prescribe SSRIs alone.
Because they make people feel more energetic, they
also interfere with sleep, which often is already a
problem for people with fibromyalgia. Studies have
shown that a combination therapy of the tricyclic
amitriptyline and the SSRI fluoxetine resulted in
greater improvements in the study participants'
fibromyalgia symptoms than either drug alone.
Mixed reuptake inhibitors—Some newer
antidepressants raise levels of both serotonin and
norepinephrine, and are therefore called mixed
reuptake inhibitors. Examples of these medications
include venlafaxine (Effexor) and nefazadone
(Serzone). Researchers are actively studying the
efficacy of these newer medications in treating
fibromyalgia.
Benzodiazepines
Benzodiazepines help some people with fibromyalgia by
relaxing tense, painful muscles and stabilizing the erratic
brain waves that can interfere with deep sleep.
Benzodiazepines also can relieve the symptoms of restless
legs syndrome, which is common among people with
fibromyalgia. Restless legs syndrome is characterized by
unpleasant sensations in the legs as well as twitching,
particularly at night. Because of the potential for addiction,
doctors usually prescribe benzodiazepines only for people
who have not responded to other therapies. Benzodiazepines
include clonazepam (Klonopin) and diazepam
(Valium).
Other medications
In addition to the previously described general categories of
drugs, doctors may prescribe others, depending on a
person's specific symptoms or fibromyalgia-related
conditions. For example, in recent years, two medications—
tegaserod (Zelnorm) and alosetron (Lotronex) - have been
approved by the FDA for the treatment of irritable bowel
syndrome. Gabapentin (Neurontin) currently is being
studied as a treatment for fibromyalgia. (See What Are
Researchers Learning About Fibromyalgia?.) Other
symptom-specific medications include sleep medications,
muscle relaxants, and headache remedies.
People with fibromyalgia also may benefit from a
combination of physical and occupational therapy, from
learning pain-management and coping techniques, and
from properly balancing rest and activity.
Complementary and alternative therapies
Many people with fibromyalgia also report varying degrees
of success with complementary and alternative therapies,
including massage, movement therapies (such as Pilates
and the Feldenkrais method), chiropractic treatments,
acupuncture, and various herbs and dietary supplements for
different fibromyalgia symptoms. (For more information on
complementary and alternative therapies, contact the
National Center for Complementary and Alternative
Medicine. See Where Can I Get More Information About
Fibromyalgia?.)
Though some of these supplements are being studied for
fibromyalgia, there is little, if any, scientific proof yet that they
help. The FDA does not regulate the sale of dietary
supplements, so information about side effects, the proper
12 dosage, and the amount of a preparation's active ingredient
may not be well known. If you are using or would like to try a
complementary or alternative therapy, you should first speak
with your doctor, who may know more about the therapy's
effectiveness, as well as whether it is safe to try in combination
with your medications.
Will Fibromyalgia Get Better With Time?
Fibromyalgia is a chronic condition, meaning it lasts a long
time - possibly a lifetime. However, it may comfort you to
know that fibromyalgia is not a progressive disease. It is never
fatal, and it won't cause damage to your joints, muscles, or
internal organs. In many people, the condition does improve
over time.
What Can I Do To Try To Feel Better?
Besides taking medicine prescribed by your doctor, there are
many things you can do to minimize the impact of
fibromyalgia on your life. These include:
- Getting enough sleep—Getting enough sleep and the
right kind of sleep can help ease the pain and fatigue of
fibromyalgia. (See Tips for Good Sleep.) Even so,
many people with fibromyalgia have problems such as
pain, restless legs syndrome, or brain-wave irregularities
that interfere with restful sleep.
- Exercising—Though pain and fatigue may make
exercise and daily activities difficult, it's crucial to be
as physically active as possible. Research has
repeatedly shown that regular exercise is one of the
most effective treatments for fibromyalgia. People who
have too much pain or fatigue to do vigorous exercise
should begin with walking or other gentle exercise
and build their endurance and intensity slowly.
Although research has focused largely on the benefits
of aerobic and flexibility exercises, a new NIAMS-supported
study is examining the effects of adding
strength training to the traditionally prescribed aerobic
and flexibility exercises.
Making changes at work—Most people with
fibromyalgia continue to work, but they may have to
make big changes to do so; for example, some people
cut down the number of hours they work, switch to a
less demanding job, or adapt a current job. If you face
obstacles at work, such as an uncomfortable desk chair
that leaves your back aching or difficulty lifting heavy
boxes or files, your employer may make adaptations
that will enable you to keep your job. An occupational
therapist can help you design a more comfortable
workstation or find more efficient and less painful
ways to lift.
If you are unable to work at all due to a medical
condition, you may qualify for disability benefits
through your employer or the Federal Government.
Social Security Disability Insurance (SSDI) and
Supplemental Security Insurance (SSI) are the
largest Federal programs providing financial
assistance to people with disabilities. Though the
medical requirements for eligibility are the same
under the two programs, the way they are funded is
different. SSDI is paid by Social Security taxes, and
those who qualify for assistance receive benefits
based on how much an employee has paid into the
system; SSI is funded by general tax revenues, and
those who qualify receive payments based on
financial need. For information about the SSDI and
SSI programs, contact the Social Security
Administration. (See Where Can I Get More
Information About Fibromyalgia?.)
- Eating well—Although some people with
fibromyalgia report feeling better when they eat or
avoid certain foods, no specific diet has been proven
to influence fibromyalgia. Of course, it is important
to have a healthy, balanced diet. Not only will
proper nutrition give you more energy and make
you generally feel better, it will also help you avoid
other health problems.
Tips for Good Sleep
- Keep regular sleep habits. Try to get to bed at the same time
and get up at the same time every day—even on weekends and
vacations.
- Avoid caffeine and alcohol in the late afternoon and evening. If
consumed too close to bedtime, the caffeine in coffee, soft
drinks, chocolate, and some medications can keep you from
sleeping or sleeping soundly. Even though it can make you feel
sleepy, drinking alcohol around bedtime also can disturb sleep.
- Time your exercise. Regular daytime exercise can improve
nighttime sleep. But avoid exercising within 3 hours of bedtime,
which actually can be stimulating, keeping you awake.
- Avoid daytime naps. Sleeping in the afternoon can interfere
with nighttime sleep. If you feel you can't get by without a nap,
set an alarm for 1 hour. When it goes off, get up and start
moving.
- Reserve your bed for sleeping. Watching the late news, reading
a suspense novel, or working on your laptop in bed can
stimulate you, making it hard to sleep.
- Keep your bedroom dark, quiet, and cool.
- Avoid liquids and spicy meals before bed. Heartburn and latenight
trips to the bathroom are not conducive to good sleep.
- Wind down before bed. Avoid working right up to bedtime.
Do relaxing activities, such as listening to soft music or
taking a warm bath, that get you ready to sleep. (An added
benefit of the warm bath: It may soothe aching muscles.)
What Are Researchers Learning About Fibromyalgia?
The NIAMS sponsors research that will improve scientists'
understanding of the specific problems that cause or
16 accompany fibromyalgia, in turn helping them develop
better ways to diagnose, treat, and prevent this syndrome.
The research on fibromyalgia supported by NIAMS covers a
broad spectrum, ranging from basic laboratory research to
studies of medications and interventions designed to
encourage behaviors that reduce pain and change behaviors
that worsen or perpetuate pain.
Following are descriptions of some of the promising
research now being conducted:
-
Understanding pain—Because research suggests that
fibromyalgia is caused by a problem in how the body
processes pain—or more precisely, a hypersensitivity
to stimuli that normally are not painful—several
NIAMS-supported researchers are focusing on ways
the body processes pain to better understand why
people with fibromyalgia have increased pain
sensitivity.
Previous research has shown that people with
fibromyalgia have reduced blood flow to parts of the
brain that normally help the body deal with pain. In
one new NIAMS-funded study, researchers will be
using imaging technology called positron emission
tomography (PET) to compare blood flow in the
brains of women who have have fibromyalgia with
those who do not. In both groups, researchers will
study changes in blood flow that occur in response to
painful stimuli.
Researchers speculate that female reproductive
hormones may be involved in the increased sensitivity to
pain characteristic of fibromyalgia. New research will
examine the role of sex hormones in pain sensitivity, in
reaction to stress, and in symptom perception at various
points in the menstrual cycles of women with
fibromyalgia and of women without it. The results from
studying these groups of women will be compared with
results from studies of the same factors in men without
fibromyalgia over an equivalent period of time.
Another line of NIAMS-funded research involves
developing a rodent model of fibromyalgia pain. Rodent
models, which use mice or rats that researchers cause to
develop symptoms similar to fibromyalgia in humans,
could provide the basis for future research into this
complex condition.
-
Understanding stress—Medical evidence suggests that
a problem or problems in the way the body responds to
physical and/or emotional stress may trigger or worsen
the symptoms of any illness, including fibromyalgia.
Researchers funded by NIAMS are trying to uncover
and understand these problems by examining chemical
interactions between the nervous system and the endocrine
(hormonal) system. Scientists know that people
whose bodies make inadequate amounts of the
hormone cortisol experience many of the same
symptoms as people with fibromyalgia, so they also are
exploring if there is a link between the regulation of
the adrenal glands, which produce cortisol, and
fibromyalgia.
Another NIAMS-funded study suggests that exercise
improves the body's response to stress by enhancing
the function of the pituitary and adrenal glands. The
hormones produced by these two endocrine glands are
essential to regulating sleep and emotions, as well as
processing pain.
-
Improving sleep—Researchers supported by NIAMS
are investigating ways to improve sleep for people
with fibromyalgia whose sleep problems persist
despite treatment with medications. One team has
observed that fibromyalgia patients with persistent
sleep problems share characteristics with people who
have insomnia, such as having erratic sleep and wake
schedules and spending too much time in bed. This
team is testing whether strategies developed to help
insomnia patients will also help people with
fibromyalgia achieve deep sleep, which eases pain and
fatigue. Preliminary results show that sleep education,
which teaches good sleep habits, and cognitive
behavioral therapy, which includes sleep education
and a regimen to correct poor habits and improper
sleep schedules, both reduce insomnia.
-
Looking for the family connection—Because
fibromyalgia appears to run in families, one group of
NIAMS-supported researchers is working to identify
whether a gene or genes predispose people to the
condition.
Another team is trying to determine if fibromyalgia is
more common in people with other conditions, such as
serious mood disorders, that tend to run in families.
Specifically, the group is studying the prevalence of
psychiatric disorders and arthritis and related disorders
in people with fibromyalgia and their first-degree
relatives (parents, children, sisters, brothers) as
compared to people with rheumatoid arthritis and
their relatives. The group is exploring whether clusters
of conditions exist in families, which might shed light
on shared common risk factors or disease processes.
-
Studying and targeting treatments—NIAMS recently
funded its first study of a drug treatment for
fibromyalgia. The study will measure the effectiveness
of gabapentin, an anticonvulsant medication, in
reducing symptoms of fibromyalgia. Gabapentin has
been found to relieve chronic pain caused by nervous
system disorders, and it was recently approved by the
FDA for the treatment of persistent, severe pain that
can follow an episode of shingles.
Scientists recognize that people with fibromyalgia
often fall into distinct subgroups that adapt to and
cope with their symptoms differently. They also realize
that these subgroups may respond to treatments
differently. One NIAMS-funded team of researchers
has divided people with fibromyalgia into three
groups based on how they cope with the condition.
Relative to other chronic pain patients, those in the
first group have higher levels of pain and report
more interference in their life due to pain. They also
have higher levels of emotional distress, and feel less
control over their lives and are less active. The
second group reports receiving less support from
others, higher levels of negative responses from
significant others, and lower levels of supportive
responses from significant others. Those in the third
group are considered adaptive copers; they have less
pain, report less interference in their lives due to
pain, and have less emotional distress. Members of
this last group feel more control over their lives and
are more active. On the premise that the better you
understand the subgroups, the better you can tailor
treatments to fit them, the researchers now are
trying to design and test different programs for each
group, combining physical therapy, interpersonal
skills training, and supportive counseling.
Where Can I Get More Information About
Fibromyalgia?
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
National Institutes of Health
1 AMS Circle
Bethesda, MD 20892-3675
Phone: 877-22-NIAMS (226-4267) (free of charge)
TTY: 301-565-2966
Fax: 301-718-6366
E-mail: NIAMSInfo@mail.nih.gov
www.niams.nih.gov
- National Center for Complementary and Alternative Medicine
National Institutes of Health
P.O. Box 7923
Gaithersburg, MD 20898-7923
Phone: 888-644-6226 (free of charge)
TTY: 866-464-3615 (free of charge)
Fax: 866-464-3616 (free of charge)
E-mail: info@nccam.nih.gov
www.nccam.nih.gov
- Social Security Administration
Office of Public Inquiries
Windsor Park Building
6401 Security Boulevard
Baltimore, MD 21235
Phone: 800-772-1213 (free of charge)
TTY: 800-325-0778 (free of charge)
www.ssa.gov/disability
- American College of Rheumatology/Association of Rheumatology Health Professionals
1800 Century Place, Suite 250
Atlanta, GA 30345-4300
Phone: 404-633-3777
Fax: 404-633-1870
www.rheumatology.org
- Advocates for Fibromyalgia Funding, Treatment, Education, and Research
P.O. Box 768
Libertyville, IL 60048-0766
Phone: 847-362-7807
Fax: 847-680-3922
E-mail: info@affter.org
www.affter.org
- Fibromyalgia Network
P.O. Box 31750
Tucson, AZ 85751-1750
Phone: 800-853-2929 (free of charge)
www.fmnetnews.com
- National Fibromyalgia Association
2200 N. Glassell Street, Suite "A"
Orange, CA 92865
Phone: 714-921-0150
www.fmaware.org
- National Fibromyalgia Partnership
P.O. Box 160
Linden, VA 22642-0160
Phone: 866-725-4404 (free of charge)
Fax: 866-666-2727 (free of charge)
E-mail: mail@fmpartnership.org
www.fmpartnership.org
- Arthritis Foundation
1330 West Peachtree Street
Atlanta, GA 30309
Phone: 404-872-7100 or
800-283-7800 (free of charge) or call your local chapter
(To find your local chapter, check your phone directory or visit the foundation's Web site.)
www.arthritis.org
Key Words
Adrenal glands—A pair of endocrine glands located on the
surface of the kidneys. The adrenal glands produce
corticosteroid hormones such as cortisol, aldosterone, and
the reproductive hormones.
Arthritis—Literally means joint inflammation, but is often
used to indicate a group of more than 100 rheumatic
diseases. These diseases affect not only the joints but also
other connective tissues of the body, including important
supporting structures, such as muscles, tendons, and
ligaments, as well as the protective covering of internal
organs.
Analgesic—A medication or treatment that relieves pain.
Connective tissue—The supporting framework of the body and its internal organs.
Chronic disease—An illness that lasts for a long time, often a lifetime.
Cortisol—A hormone produced by the adrenal cortex,
important for normal carbohydrate metabolism and for a healthy response to stress.
Fibrous capsule—A tough wrapping of tendons and
ligaments that surrounds the joint.
Fibromyalgia—A chronic syndrome that causes pain and
stiffness throughout the connective tissues that support and
move the bones and joints. Pain and localized tender points
occur in the muscles, particularly those that support the
neck, spine, shoulders, and hip. The disorder includes
widespread pain, fatigue, and sleep disturbances.
Inflammation—A characteristic reaction of tissues to injury or disease. It is marked by four signs: swelling, redness,
heat, and pain. Inflammation is not a symptom of fibromyalgia.
Joint—A junction where two bones meet. Most joints are composed of cartilage, joint space, fibrous capsule, synovium, and ligaments.
Ligaments—Bands of cordlike tissue that connect bone to bone.
Muscle—A structure composed of bundles of specialized
cells that, when stimulated by nerve impulses, contract and produce movement.
Nonsteroidal anti-inflammatory drugs (NSAIDs)—A group of drugs, such as aspirin and aspirin-like drugs, used to reduce inflammation that causes joint pain, stiffness, and swelling.
Pituitary gland—A pea-sized gland attached beneath the hypothalamus at the base of the skull that secretes many
hormones essential to bodily functioning. The secretion of
pituitary hormones is regulated by chemicals produced in
the hypothalamus.
Sleep disorder—A disorder in which a person has difficulty achieving restful, restorative sleep. In addition to other
symptoms, people with fibromyalgia usually have a sleep disorder.
Tender points—Specific places on the body where a person with fibromyalgia feels pain in response to slight pressure.
Tendons—Fibrous cords that connect muscle to bone.
Acknowledgments
The NIAMS gratefully acknowledges the assistance of Deborah Ader, Ph.D.,
NIAMS, NIH; Karen Amour and Lynne Matallana, National Fibromyalgia
Association, Orange, CA; Michele L. Boutaugh, M.P.H., Arthritis Foundation,
Atlanta, GA; Daniel Clauw, M.D., and Leslie Crofford, M.D., University of
Michigan, Ann Arbor; and Tamara Liller, National Fibromyalgia Partnership,
Linden, VA, in the preparation of this booklet.
The mission of the National Institute of Arthritis and
Musculoskeletal and Skin Diseases (NIAMS), a part of the
Department of Health and Human Services' National Institutes
of Health (NIH), is to support research into the causes,
treatment, and prevention of arthritis and musculoskeletal and
skin diseases, the training of basic and clinical scientists to carry
out this research, and the dissemination of information on
research progress in these diseases. The National Institute of
Arthritis and Musculoskeletal and Skin Diseases Information
Clearinghouse is a public service sponsored by the NIAMS that
provides health information and information sources. Additional
information can be found on the NIAMS Web site at
www.niams.nih.gov.
NIH Publication NO. 04-5326
June 2004