How Are Autoimmune Diseases
Diagnosed?
Autoimmune diseases often don't show a clear pattern of
symptoms at first. So diagnosing them can be hard. But with time, a
diagnosis can usually be made by using:
- Medical history--The doctor will ask about your symptoms
and how long you have had them. Your symptoms may not point to one
disease. But they can be a starting point for your doctor. You should
tell your doctor if you have a family member with autoimmune disease.
You may not have the same disease as your family member. But having
a family history of any autoimmune disease makes you more likely to
have one.
- Physical exam--During the exam, the doctor will check for
any signs. Inflamed joints, swollen lymph nodes, or discolored skin
might give clues.
- Medical tests--No one test will show that you have an autoimmune
disease. But doctors may find clues in a blood sample. For example,
people with lupus or rheumatoid arthritis often have certain autoantibodies
in their blood. Autoantibodies are blood proteins formed against the
body's own parts.
Not all people with these diseases have these autoantibodies. And
some people without autoimmune disease do have them. So blood tests
alone may not always help. But if a person has disease symptoms
and autoantibodies, the doctor can be more sure of a diagnosis.
The key is patience. Your doctor may be able to diagnose
your condition quickly based on your history, exam, and test results.
But the process often takes time. It may take several visits to find
out exactly what's wrong and the best way to treat it.
How Are Autoimmune Diseases
Treated?
Autoimmunity takes many forms. There are also many treatments
for it. Treatment depends on the type of disease, how severe it is,
and its symptoms. Generally, treatments have one of three goals:
- Relieving symptoms--If your symptoms bother you, your doctor
may suggest treatments that give some relief. Relieving symptoms may
be as simple as taking a drug for pain relief. It may also be as involved
as having surgery.
- Preserving organ function--When autoimmune diseases threaten
organs, treatment may be needed to prevent damage. Such treatments
may include drugs to control an inflamed kidney in people with lupus.
Insulin injections can regulate blood sugar in people with diabetes.
These treatments don't stop the disease. But they can save organ function.
They can also help people live with disease complications.
- Targeting disease mechanisms--Some drugs may also be used
to target how the disease works. In other words, they can suppress
the immune system. These drugs include cyclophosphamide (Cytoxan*)
and cyclosporine (Neoral and Sandimmune). The same immune-suppressing
drug may be used for many diseases.
Your doctor may not prescribe a treatment. If your symptoms
are mild, the risks of treatment may be worse than the symptoms. You
may choose to put off treatment for now. But you should watch for signs
that your disease is progressing. Visit your doctor regularly. You need
to catch changes before they lead to serious damage.
*Brand names included in this booklet are provided as
examples only, and their inclusion does not mean that these products
are endorsed by the National Institutes of Health or any other Government
agency. Also, if a particular brand name is not mentioned, this does
not mean or imply that the product is unsatisfactory.
What Types of Doctors Treat
Autoimmune Diseases?
Treatments for autoimmune diseases vary. So do the types
of doctors who provide them.
For some people, one doctor will be enough to manage their
disease. Others may require a team approach. One doctor might coordinate
and give care, and others would treat specific organ problems. For example,
a person with lupus might be seen by a rheumatologist. But that person
might also see a nephrologist for related kidney problems and a dermatologist
for skin problems.
Specialists you may need to see include:
- A rheumatologist, who treats arthritis and other rheumatic diseases.
These include scleroderma and systemic lupus erythematosus (lupus
or SLE).
- An endocrinologist, who treats gland and hormone problems. These
include diabetes and thyroid disease.
- A neurologist, who treats nerve problems. These include multiple
sclerosis and myasthenia gravis.
- A hematologist, who treats diseases that affect the blood. These
include pernicious anemia and autoimmune hemolytic anemia.
- A gastroenterologist, who treats problems with the digestive system.
These include Crohn's disease and ulcerative colitis.
- A dermatologist, who treats problems of the skin, hair, and nails.
These include psoriasis, pemphigus/pemphigoid, and alopecia areata.
- A nephrologist, who treats kidney problems. These include glomerulonephritis,
inflamed kidneys associated with lupus.
What Are Some Other Problems
Related to Autoimmune Diseases?
Having a chronic disease can affect almost every part
of your life. The problems you might have with an autoimmune disease
vary. They may include:
- How you look and your self-esteem--Depending on your disease,
you may have discolored or damaged skin or hair loss. Your joints
may look different. These can all affect how you look and your self-esteem.
Such problems can't always be prevented. But their effects can be
reduced with treatment. Cosmetics, for example, can hide a skin rash.
Surgery can correct a malformed joint.
- Caring for yourself--Painful joints or weak muscles can make
it hard to do simple tasks. You may have trouble climbing stairs,
making your bed, or brushing your hair. If doing daily tasks is hard,
talk with a physical therapist. The therapist can teach you exercises
to improve strength and function. An occupational therapist can show
you new ways to do things or tools to make tasks easier. Sometimes
regular exercise or simple devices can help you do more things on
your own.
- Family relationships--Family members may not understand why
you don't have energy to do things you used to do. They may even think
you are just being lazy. But they may also be overly concerned and
eager to help you. They may not let you do the things you can do.
They may even give up their own interests to be with you. Learn as
much as you can about your disease. Share what you learn with your
family. Involve them in counseling or a support group. It may help
them better understand the disease and how they can help.
- Sexual relations--Sexual relationships can also be affected.
For men, diseases that affect blood vessels can lead to problems with
erection. In women, damage to glands that produce moisture can lead
to vaginal dryness. This makes intercourse painful. In both men and
women, pain, weakness, or stiff joints may make it hard for them to
move the way they once did. They may not be sure about how they look.
Or they may be afraid that their partner will no longer find them
attractive. With communication, good medical care, and perhaps counseling,
many of these issues can be overcome or at least worked around.
- Pregnancy and childbearing--In the past, women with some
autoimmune diseases were told not to have children. But better treatments
and understanding have changed that advice. Autoimmune diseases can
affect pregnancy, and pregnancy can affect autoimmune diseases. But
women with many such diseases can safely have children. How a pregnancy
turns out can vary by disease and disease severity. If you have an
autoimmune disease, you should consult your doctor about having children.
What Research Is Being
Conducted To Help People With Autoimmune Diseases?
The National Institutes of Health (NIH) supports research
in autoimmune diseases. Here are a few examples:
- Rheumatoid arthritis--The National Institute of Arthritis
and Musculoskeletal and Skin Diseases (NIAMS) and the North American
Rheumatoid Arthritis Consortium will study 1,000 siblings with rheumatoid
arthritis. Scientists will look at gene material to find and identify
parts of DNA involved in the disease. They will test for proteins
called rheumatoid factor in the blood. And they will look at x rays
of the joints. This work will provide basic facts about the genetics
of the disease.
- Systemic lupus erythematosus (SLE)--NIAMS-supported scientists
are studying whether women with lupus can safely take oral contraceptives
or hormone replacement therapy. Previous research suggests that female
hormones may contribute to the disease or make it worse.
- Lupus nephritis--One NIAMS project is testing a drug that
may be less toxic than the drugs now used for lupus nephritis (kidney
disease caused by lupus).
- Vitiligo--With NIAMS support, scientists are studying genes
from pairs of siblings affected by this skin pigmentation disorder.
They hope to find genes that may cause vitiligo and learn how they
affect the skin.
- Type 1 diabetes--Researchers supported by the National Institute
of Diabetes and Digestive and Kidney Diseases have found a way to
identify people who are likely to get type 1 diabetes (formerly known
as juvenile diabetes). They are now testing ways to prevent these
people from getting the disease.
- Multiple sclerosis--Scientists supported by the National
Institute of Neurological Disorders and Stroke are looking at the
autoimmune system, infectious agents, and genes as culprits in multiple
sclerosis (MS). Such studies strengthen the theory that MS comes from
a number of factors rather than a single one. Studies use magnetic
resonance imaging to see how MS lesions evolve in the brain's white
matter. Research has shown that MS has no bad effects on pregnancy,
labor, or delivery. In fact, the stabilizing or remission of symptoms
during pregnancy may be due to changes in a woman's immune system
that allow her to carry a baby.
- Multiple autoimmune diseases--The National Institute of
Allergy and Infectious Diseases is supporting clinical trials of drugs
that prevent the immune system from attacking healthy cells. The Institute
wants to see if they are safe and useful. Such drugs may prove helpful
for treating a number of autoimmune diseases.
Where Can People Find More
Information About Autoimmunity?
Various parts of the NIH provide information on different
aspects of autoimmune diseases. Many nonprofit organizations have patient
resources, local chapters, and support groups. Your own doctor can best
tell you about your own medical condition.
National Institutes of Health
National Institute of Arthritis and Musculoskeletal
and Skin Diseases (NIAMS)
1 AMS Circle
Bethesda, MD 20892-3675
Phone: 301-495-4484 or 877-22-NIAMS (226-4267) (free of charge)
TTY: 301-565-2966
Fax: 301-718-6366
www.niams.nih.gov
National Institute of Allergy and Infectious Diseases
Office of Communications
Building 31, Room 7A50
31 Center Drive, MSC 2520
Bethesda, MD 20892-2520
Phone: 301-496-5717
www.niaid.nih.gov/publications
and
www.niaid.nih.gov/clintrials/default.htm
(for clinical trials information)
National Institute of Diabetes and Digestive and Kidney
Diseases (NIDDK)
National Diabetes Information Clearinghouse (NDIC)
1 Information Way
Bethesda, MD 20892-3560
Phone: 301-654-3327 or 800-860-8747 (free of charge)
Email: ndic@info.niddk.nih.gov
www.niddk.nih.gov
National Institute of Neurological Disorders and Stroke
Office of Scientific and Health Reports
P.O. Box 5801
Bethesda, MD 20824
Phone: 301-496-5751 or 800-352-9424 (free of charge)
www.ninds.nih.gov
NIH Clinical Center
Patient Recruitment and Public Liaison--for specific
NIH clinical trials information
Building 60
10 Cloister Court
Bethesda, MD 20892-4754
Phone: 800-411-1222 (free of charge)
TTY: 866-411-1010
E-mail: prpl@mail.cc.nih.gov
http://clinicalstudies.info.nih.gov/referring_patient.html
Office of Rare Diseases
Building 31, Room 1B19
31 Center Drive
Bethesda, MD 20892
Phone: 301-402-4336
http://rarediseases.info.nih.gov
Other Resources Sponsored by the U.S.
Department of Health and Human Services
Combined Health Information Database
www.chid.nih.gov
National Health Information Center
Phone: 301-565-4167 or 800-336-4797 (free of charge)
Health Finder: www.healthfinder.gov
Other Organizations
American Academy of Orthopaedic Surgeons
P.O. Box 2058
Des Plaines, IL 60017
Phone: 800-824-BONE (2663) (free of charge)
www.aaos.org
American College of Rheumatology
1800 Century Place, Suite 250
Atlanta, GA 30345
Phone: 404-633-3777
Fax: 404-633-1870
E-mail: acr@rheumatology.org
www.rheumatology.org
American Autoimmune Related Diseases Association
22100 Gratiot Avenue
Eastpointe
East Detroit, MI 48201-2227
Literature requests: 800-598-4668 (free of charge)
Phone: 586-776-3900
Fax: 586-776-3903
E-mail: aarda@aarda.org
www.aarda.org
American Behçet's Disease Association
P.O. Box 15247
Chattanooga, TN 37415-0240
Phone: 800-7-BEHCET (723-4238) (free of charge)
www.behcets.com
American Diabetes Association
Attn: Customer Service
1701 N. Beauregard Street
Alexandria, VA 22311
Phone: 800-DIABETES (342-2383) (free of charge)
www.diabetes.org
American Liver Foundation
75 Maiden Lane, Suite 603
New York, NY 10038
Phone: 973-256-2550 or 800-443-7222 (free of charge)
www.liverfoundation.org
Arthritis Foundation
1330 West Peachtree Street
Atlanta, GA 30309
Phone: 800-283-7800 (free of charge)
www.arthritis.org
Crohn's and Colitis Foundation of America
National Headquarters
386 Park Avenue South, 17th Floor
New York, NY 10016-8804
Phone: 800-932-2423 (free of charge)
800-343-3637 (Warehouse)
www.ccfa.org
Guillain-Barré Syndrome Foundation International
P.O. Box 262
Wynnewood, PA 19096
Phone: 610-667-0131
Fax: 610-667-7036
E-mail: gbint@ix.netcom.com
www.guillain-barre.com
Juvenile Diabetes Research Foundation International
120 Wall Street
New York, NY 10005-4001
Phone: 212-785-9500 or 800-JDF-CURE (533-2873) (free of charge)
Fax: 212-785-9595
E-mail: info@jdrf.org
www.jdf.org
Lupus Foundation of America, Inc. (LFA)
2000 L Street, N.W., Suite 710
Washington, DC 20036
Phone: 202-349-1155
Toll-Free: (800)558-0121
Fax: 202-349-1156
E-mail: lupusinfo@lupus.org
www.lupus.org
Myasthenia Gravis Foundation of America
5841 Cedar Lake Road, Suite 204
Minneapolis, MN 55416
Phone: 952-545-9438 or 800-541-5454 (free of charge)
Fax: 952-545-6073
E-mail: myasthenia@myasthenia.org
www.myasthenia.org
Myositis Association
1233 20th Street, NW, Suite 402
Washington DC 20036
Phone: 202-887-0088
Toll-free: 800-821-7356
Fax: 202-466-8940
E-mail: tma@myositis.org
www.myositis.org
National Adrenal Diseases Foundation
505 Northern Boulevard
Great Neck, NY 11021
Phone: 516-487-4992
E-mail: nadfmail@aol.com
www.medhelp.org/nadf
National Alopecia Areata Foundation
14 Mitchell Boulevard
San Rafael, CA 94903
or
P.O. Box 150760
San Rafael, CA 94915
Phone: 415-472-3780
Fax: 415-472-5343
www.naaf.org
National Multiple Sclerosis Society
733 Third Avenue, 6th Floor
New York, NY 10017-3288
Phone: 212-986-3240 or 800-344-4867 (free of charge)
Fax: 212-986-7981
E-mail: info@nmss.org
www.nmss.org
National Organization for Rare Diseases
P.O. Box 8923
New Fairfield, CT 06812-1783
Phone: 203-746-6518 or 800-999-6673 (free of charge)
Fax: 203-746-6481
www.rarediseases.org
International Pemphigus Foundation
828 San Pablo Avenue, Suite 210
Albany, CA 94706
Phone: 510-527-4970
Fax: 510-527-9497
E-mail: pemphigus@pemphigus.org
www.pemphigus.org
National Psoriasis Foundation
6600 SW 92nd Avenue, Suite 300
Portland, OR 97223-7195
Phone: 503-244-7404 or 800-723-9166 (free of charge)
Fax: 503-245-0626
E-mail: getinfo@npfusa.org
www.psoriasis.org
National Vitiligo Foundation
700 Olympic Plaza Circle, Suite 404
Tyler, TX 75701
Phone: (903) 595-3713
Fax: (903) 593-1545
E-mail: info@nvfi.org
www.nvfi.org/index.html
Scleroderma Foundation
12 Kent Way, Suite 101
Bayfield, MA 01922
Phone: 978-463-5843
Info line: 800-722-HOPE (4673) (free of charge)
Fax: 978-463-5809
E-mail: sfinfo@scleroderma.org
www.scleroderma.org
Scleroderma Research Foundation
2320 Bath Street, Suite 315
Santa Barbara, CA 93105
Phone: 805-563-9133 or
800-441-CURE (2873) (free of charge)
Fax: 805-563-2402
E-mail: srfcure@srfcure.org
www.srfcure.org
Sjögren's Syndrome Foundation
8120 Woodmont Avenue, Suite 530
Bethesda, MD 20814
Phone: 301-718-0300
or 800-4-SJOGRENS (475-6473) (free of charge)
Fax: 301-718-0322
E-mail: ssf@sjogrens.org
www.sjogrens.org or www.sjogrens.com
Spondylitis Association of America
P.O. Box 5872
Sherman Oaks, CA 91413
Phone: 800-777-8189 or 888-777-1594 (free of charge)
www.spondylitis.org
SLE Foundation, Inc.
149 Madison Avenue, Suite 205
New York, NY 10016
Phone: 212-685-4118
Fax: 212-545-1843
E-mail: lupus@lupusny.org
www.lupusny.org
Thyroid Foundation of America, Inc.
410 Stuart Street
Boston, MA 02116
Phone: 617-534-1500 or 800-832-8321 (free of charge)
Fax: 617-534-1515
E-mail: info@tsh.org
www.allthyroid.org
Wegener's Association
P.O. Box 28660
Kansas City, MO 64188-8668
Phone: 800-277-9474 (free of charge)
Phone/Fax: 816-436-8211
E-mail: wga@wgassociation.org
www.wgassociation.org
Appendix I: Glossary of Terms
Antibodies--Special proteins produced by the body's
immune system that help fight and destroy viruses, bacteria, and other
foreign substances that invade the body.
Antigen--A substance (usually foreign) that stimulates
the immune response. In people with autoimmune disease, the body's own
cells may be seen as antigens.
Autoantibodies--Abnormal antibodies that attack
parts of the body, causing autoimmune disease.
Autoimmune disease--A disease that occurs when
the immune system turns against parts of the body it is designed to
protect.
Fever--A rise in body temperature caused by the
immune system's response to infection or disease.
Immune response--The reaction of the immune system
against foreign substances. When the reaction occurs against the body's
own cells or tissues, it is called an autoimmune reaction.
Immune system--A complex system that normally protects
the body from infections. The immune system consists of a group of cells,
the chemicals that control those cells, and the chemicals that those
cells release.
Immunosuppressive drugs--Drugs that suppress the
immune response and can be used to treat autoimmune disease. Unfortunately,
because normal immunity is also suppressed with these drugs, they leave
the body at risk for infection.
Infection--Invasion of the body tissues by bacteria
or other tiny organisms that cause illness.
Inflammation--A reaction of tissues to injury or
disease, typically marked by four signs: swelling, redness, heat, and
pain.
Trigger--Something that either sets off a disease
in people who are genetically predisposed to developing the disease,
or that causes a certain symptom to occur in a person who has a disease.
For example, sunlight can trigger rashes in people with lupus.
Appendix II: Glossary of
Diseases
Autoimmunity plays a role in more than 80 diseases. Following
are brief descriptions of some of the many diseases in which autoimmunity
may be involved.
Note: Because the specific causes of many diseases
are unknown, there is debate among scientists about whether some of
these are truly autoimmune diseases. Your own doctor may classify some
of these diseases differently.
Alopecia areata--A disorder in which the immune
system attacks the hair follicles, causing loss of hair on the scalp,
face, and other parts of the body.
Ankylosing spondylitis--A rheumatic disease that
causes inflamed joints in the spine and sacroiliac (the joints that
connect the spine and the pelvis) and, in some people, inflamed eyes
and heart valves.
Arthritis--A general term for more than 100 different
diseases that affect the joints. Many forms of arthritis and related
conditions are believed to have an autoimmune component.
Autoimmune hemolytic anemia--A condition in which
immune system proteins attack the red blood cells, resulting in fewer
of these oxygen-transporting cells.
Autoimmune hepatitis--A disease in which the body's
immune system attacks liver cells, causing inflammation. If not stopped,
inflammation can lead to cirrhosis (scarring and hardening) of the liver
and eventually liver failure.
Behçet's disease--A condition characterized
by sores in the mouth and on the genitals and by inflammation in parts
of the eye. In some people, the disease also results in inflammation
of the joints, digestive tract, brain, and spinal cord.
Crohn's disease--An inflammatory disease of the
small intestine or colon that causes diarrhea, cramps, and excessive
weight loss.
Dermatomyositis--A rare autoimmune disease that
causes patchy red rashes around the knuckles, eyes, and other parts
of the body along with chronic inflammation of the muscles. It may occur
along with other autoimmune diseases such as rheumatoid arthritis or
systemic lupus erythematosus.
Diabetes mellitus, type 1--A condition in which
the immune system destroys insulin-producing cells of the pancreas,
making it impossible for the body to use glucose (blood sugar) for energy.
Type 1 diabetes usually occurs in children and young adults.
Glomerulonephritis--Inflammation of the kidney's
tiny filtering units, which in severe cases can lead to kidney failure.
Graves' disease--An autoimmune disease of the thyroid
gland that results in the overproduction of thyroid hormone. This causes
such symptoms as nervousness, heat intolerance, heart palpitations,
and unexplained weight loss.
Guillain-Barré syndrome--A disorder in which
the body's immune system attacks part of the nervous system, leading
to numb, weak limbs and, in severe cases, paralysis.
Inflammatory bowel disease--The general name for
diseases that cause inflammation in the intestine, the most common of
which are ulcerative colitis and Crohn's disease.
Lupus nephritis--Damaging inflammation of the kidneys
that can occur in people with lupus. If not controlled, it may lead
to total kidney failure.
Multiple sclerosis--A disease in which the immune
system attacks the protective coating called myelin around the nerves.
The damage affects the brain and/or spinal cord and interferes with
the nerve pathways, causing muscular weakness, loss of coordination,
and visual and speech problems.
Myasthenia gravis--A disease in which the immune
system attacks the nerves and muscles in the neck, causing weakness
and problems with seeing, chewing, and/or talking.
Myocarditis--Inflamed and degenerating muscle tissue
of the heart that can cause chest pain and shortness of breath. This
can lead to congestive heart failure.
Pemphigus/pemphigoid--An autoimmune disease of
the skin characterized by itching and blisters.
Pernicious anemia--A deficiency of the oxygen-carrying
red blood cells that often occurs in people with autoimmune diseases
of the thyroid gland.
Polyarteritis nodosa--An autoimmune disease that
causes inflammation of the small and medium-sized arteries. This leads
to problems in the muscles, joints, intestines, nerves, kidney, and
skin.
Polymyositis--A rare autoimmune disease characterized
by inflamed and tender muscles throughout the body, particularly those
of the shoulder and hip girdles.
Primary biliary cirrhosis--A disease that slowly
destroys the bile ducts in the liver. When the ducts are damaged, bile
(a substance that helps digest fat) builds up in the liver and damages
liver tissue.
Psoriasis--A chronic skin disease that occurs when
cells in the outer layer of the skin reproduce faster than normal and
pile up on the skin's surface. This results in scaling and inflammation.
An estimated 10 to 30 percent of people with psoriasis develop an associated
arthritis called psoriatic arthritis.
Rheumatic fever--A disease that can occur following
untreated streptococcus (strep) infection. It most often affects children,
causing painful, inflamed joints and, in some cases, permanent damage
to heart valves.
Rheumatoid arthritis--A disease in which the immune
system is believed to attack the linings of the joints. This results
in joint pain, stiffness, swelling, and destruction.
Sarcoidosis--A disease characterized by granulomas
(small growths of blood vessels, cells, and connective tissue) that
can lead to problems in the skin, lungs, eyes, joints, and muscles.
Scleroderma--An autoimmune disease characterized
by abnormal growth of connective tissue in the skin and blood vessels.
In more severe forms, connective tissue can build up in the kidneys,
lungs, heart, and gastrointestinal tract, leading in some cases to organ
failure.
Sjögren's syndrome--A condition in which the
immune system targets the body's moisture-producing glands, leading
to dryness of the eyes, mouth, and other body tissues.
Systemic lupus erythematosus--An autoimmune disease,
primarily of young women, that can affect many parts of the body, including
the joints, skin, kidneys, heart, lungs, blood vessels, and brain.
Thyroiditis--An inflammation of the thyroid gland
that causes the gland to become underactive. This results in symptoms
such as fatigue, weakness, weight gain, cold intolerance, and muscle
aches.
Ulcerative colitis--A disease that causes ulcers
in the top layers of the lining of the large intestine. This leads to
abdominal pain and diarrhea.
Uveitis--The inflammation of structures of the
inner eye, including the iris (the colored tissue that holds the lens
of the eye) and the choroid plexus (a network of blood vessels around
the eyeball). Uveitis occurs with some rheumatic diseases, including
ankylosing spondylitis and juvenile rheumatoid arthritis.
Vitiligo--A disorder in which the immune system
destroys pigment-making cells called melanocytes. This results in white
patches of skin on different parts of the body.
Wegener's granulomatosis--An autoimmune disease
that damages the small and medium-sized blood vessels throughout the
body, resulting in disease in the lungs, upper respiratory tract, and
kidneys.
Acknowledgments
The NIAMS gratefully acknowledges the assistance of
Jill Buyon, M.D., of New York University Medical Center, New York, NY;
Elaine Collier, M.D., of the National Institute of Allergy and Infectious
Diseases, NIH; Elizabeth Gretz, M.D., of NIAMS, NIH; Peter Lipsky, M.D.,
of NIAMS, NIH; Michael Lockshin, M.D., of the Hospital for Special Surgery,
New York, NY; Barbara Mittleman, M.D., of NIAMS, NIH; Alan Moshell,
M.D., of NIAMS, NIH; and Noel Rose, M.D., Ph.D., of the Johns Hopkins
University School of Hygiene and Public Health, Baltimore, MD, in the
preparation and review of this booklet. Mary Anne Dunkin was the primary
author of this booklet.
The mission of the National Institute of Arthritis and
Musculoskeletal and Skin Diseases (NIAMS), a part of the National Institutes
of Health (NIH), is to support research into the causes, treatment,
and prevention of arthritis and musculoskeletal and skin diseases, the
training of basic and clinical scientists to carry out this research,
and the dissemination of information on research progress in these diseases.
The National Institute of Arthritis and Musculoskeletal and Skin Diseases
Information Clearinghouse is a public service sponsored by the NIAMS
that provides health information and information sources. Additional
information can be found on the NIAMS Web site at www.niams.nih.gov.
This booklet is not copyrighted. Readers are encouraged
to duplicate and distribute as many copies as needed.
Additional copies of this booklet are available from
National Institute of Arthritis and Musculoskeletal
and Skin Diseases
NIAMS/National Institutes of Health (NIH)
1 AMS Circle
Bethesda, MD 20892-3675
NIH Publication No. 02-4858