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Division of Intramural Research
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Overview |
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Organizational Chart |
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Research Branches
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Research Investigators
Profiles, publications, links |
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Clinical Research
Clinical trials, patient recruitment, IRB, FAQ, Overview |
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NHGRI Affiliated Centers
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Online Research Resources Developed at NHGRI
Databases, software, tools, more. |
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Division of Intramural Research Calendar
Workshops, conferences, seminar series, courses, more. |
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Books and Publications |
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Genetics and Molecular Biology Branch
The Genetics and Molecular Biology Branch uses molecular genetics to identify and characterize genes involved in the normal development and function of many tissues. Blood cells, cells of the immune system and epithelial cells are studied, with particular emphasis on stem cells with their dual capabilities of self-renewal and differentiation into multiple, committed lineages. Yeast cells are used as a model system to study genome replication and stability.
Investigations in this branch are designed to identify disease-associated gene defects and to understand how gene defects contribute to human diseases like anemia, cancer and immune disorders. Researchers study how genes normally act, what the consequences are when they have mutations, and how these consequences might be overcome by development of effective treatments. An important method used in this branch is gene transfer: the introduction of genes into cells to correct the effects of mutations in the cellular DNA. Studies using cell lines and animal models lead not only to basic information about gene function in health and disease, but also to human clinical trials of gene transfer for therapy of genetic diseases.
Principal Investigators
Jennifer M. Puck, M.D.
Senior Investigator and Chief, Genetics and Molecular Biology Branch
Head, Immunologic Genetics Section
David M. Bodine, Ph.D.
Senior Investigator, Genetics and Molecular Biology Branch
Head, Hematopoiesis Section
Fabio Candotti, M.D.
Senior Investigator, Genetics and Molecular Biology Branch
Head, Disorders of Immunity Section
Pu Paul Liu, M.D., Ph.D.
Senior Investigator, Genetics and Molecular Biology Branch
Head, Oncogenesis and Development Section
Kyungjae Myung, Ph.D.
Investigator, Genetics and Molecular Biology Branch
Head, Genome Instability Section
Julie A. Segre, Ph.D.
Investigator, Genetics and Molecular Biology Branch
Head, Epithelial Biology Section
Associate Investigator
Raman B. Sood, Ph.D.
Associate Investigator, Genetics and Molecular Biology Branch
Research Project Web Sites
Autoimmune Lymphoproliferative Syndrome Database (ALPSbase)
X-Linked SCID Mutation Database Database (IL2RGbase)
Last Updated: June 2004
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