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The NCI's Radiation Oncology Sciences Program (ROSP) is developing a translational research program that will closely link molecular imaging, cancer signatures, and molecular targets. This will allow serial imaging with conventional and innovative technology and serial biopsies to assess genomics and proteomics to be coupled with therapeutic intervention using systemic agents, radiation therapy and immunologic treatment, and chemopreventative agents. The ability to conduct multiple studies will provide a robust data set by which to understand the biology behind the image to credential new molecular targets.

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