The NCI has defined new, extraordinary research opportunities
as part of its mission to "
translate scientific knowledge into more
effective cancer interventions." The goal is to create an integrated,
multidisciplinary research environment that brings together scientists from
diverse fields to work on the "big picture" problems in cancer
research. Collaboration, technology support and development, and access
to resources are critical to achieving this goal. The CCR has responded
to this challenge by establishing faculties and other groups-composed of
basic and clinical researchers-that are focusing on:
Molecular Targets
One high priority is identifying and using molecular targets for the discovery
and clinical testing of new anticancer agents based on the molecular mechanisms
that underlie neoplastic transformations, cancer growth, and metastasis.
Cancer Prevention Models
The Prevention Models Focus Group is enhancing research studies that can
provide insight into genes whose activity drives or prevents carcinogenesis
at any stage.
Breast
Cancer
The Breast Cancer Faculty is a community of investigators at NCI, NIH,
and beyond, who focus on the prevention and cure of this disease.
Microarray Technology
NCI's Advanced Technology Center (ATC) and the Laboratory of Molecular
Technology (SAIC Frederick) are developing new microarray technologies
for human and mouse studies.
Proteomics
CCR is expanding its proteomics effort to study the protein composition
of normal and tumor cells and then apply this research to patient diagnosis,
toxicity monitoring, and therapeutics.
Imaging
A translational (bench-to-bedside) research program will closely link
molecular imaging, cancer signatures, and molecular targets.
Molecular Pathology
Diagnostic and laboratory medicine capabilities are available to investigators
studying the molecular events that occur during the development, growth,
and metastasis of cancer in preclinical models.
Genomic Analysis
A bioinformatics network is being developed within CCR to enhance the
utilization of genomics information from commercial and public databases
as well as to support Center initiatives in microarray technology and
proteomics.
Office of Mice Advice
Having problems related to research animal issues? Assistance is now
available-This Office is here to help NCI research and administration
staff with areas ranging from animal study proposal development, murine
genetics and husbandry to understanding billing procedures.
Animal Models
Animals models of cancer and related disorders are the focus of this effort,
which aims to enhance resources, technology, and training in this important area.
Related Links:
NCI Extraordinary Research
Opportunities
