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Butorphanol
While butorphanol
can be made from thebaine, it is usually manufactured synthetically. It
was initially available in injectable formulations for human (Stadol®)
and veterinary (Torbugesic® and Torbutrol®) use. More recently,
a nasal spray (Stadol NS®) became available, and significant diversion
and abuse of this product led to the 1997 control of butorphanol in Schedule
IV of the CSA. Butorphanol is a clear example of a drug gaining favor
as a drug of abuse only after it became available in a form that facilitated
its mode of administration (nasal spray v. injection).
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