The names of current senators appear in bold print.
| Senator | Party/State | Term | |
|---|---|---|---|
| Elmer, Jonathan | (Pro-Admin-NJ) | 1789-1791 | |
 | Bradford, William | (Pro-Admin/F-RI) | 1793-1797 |
 | Latimer, Henry | (F-DE) | 1795-1801 |
 | Clayton, Joshua | (F-DE) | 1798 |
 | Logan, George** | (R-PA) | 1801-1807 |
 | Condit, John | (R-NJ) | 1803-1817 |
 | Mitchill, Samuel Latham | (R-NY) | 1804-1809 |
 | Jones, George | (R-GA) | 1807 |
 | Tiffin, Edward | (R-OH) | 1807-1809 |
 | Campbell, Alexander | (R-OH) | 1809-1813 |
 | Leib, Michael | (R-PA) | 1809-1814 |
 | Hunter, William* | (F-RI) | 1811-1821 |
 | Bibb, William Wyatt | (R-GA) | 1813-1816 |
 | Storer, Clement | (R-NH) | 1817-1819 |
 | Morril, David L. | (R-NH) | 1817-1823 |
 | Pinkney, William** | (R-MD) | 1819-1822 |
 | Ware, Nicholas* | (R/CRR-GA) | 1821-1824 |
 | Chambers, Henry H. | (J-AL) | 1825-1826 |
 | Harrison, William Henry** | (Adams-OH) | 1825-1828 |
 | Harper, William* | (J-SC) | 1826 |
 | Bateman, Ephraim | (Adams-NJ) | 1826-1829 |
 | Naudain, Arnold | (AJ-DE) | 1830-1836 |
 | Kent, Joseph | (AJ/W-MD) | 1833-1837 |
 | Linn, Lewis Fields | (J/D-MO) | 1833-1843 |
| Spence, John Selby | (Anti-Jackson/W-MD) | 1836-1840 | |
 | Sturgeon, Daniel | (D-PA) | 1840-1851 |
 | Borland, Solon | (D-AR) | 1848-1853 |
 | Gwin, William M. | (D-CA) | 1850-1855, 1857-1861 |
 | Wade, Benjamin F.* | (W/OP/R-OH) | 1851-1869 |
 | Nourse, Amos | (R-ME) | 1857 |
 | Bates, Martin Waltham* | (D-DE) | 1857-1859 |
 | Fitch, Graham Newell | (D-IN) | 1857-1861 |
 | Mitchel, Charles Burton | (D-AR) | 1861 |
 | Cowan, Edgar* | (R-PA) | 1861-1867 |
 | Miller, Homer Virgil Milton | (D-GA) | 1871 |
 | Conover, Simon Barkley | (R-FL) | 1873-1879 |
 | Dennis, George Robertson | (D-MD) | 1873-1879 |
 | Withers, Robert Enoch | (D-VA) | 1875-1881 |
 | Chilcott, George Miles** | (R-CO) | 1882-1883 |
 | Gallinger, Jacob Harold | (R-NH) | 1891-1918 |
 | Deboe, William Joseph | (R-KY) | 1897-1903 |
 | Ball, Lewis Heisler | (R-DE) | 1903-1905, 1919-1925 |
| Lane, Harry | (D-OR) | 1913-1917 | |
 | France, Joseph Irvin | (R-MD) | 1917-1923 |
 | Copeland, Royal S. | (D-NY) | 1923-1938 |
 | Ferris, Woodbridge Nathan | (D-MI) | 1923-1928 |
 | Hatfield, Henry D. | (R-WV) | 1929-1935 |
 | Gruening, Ernest** | (D-AK) | 1959-1969 |
 | Frist, William H. | (R-TN) | 1995-2007 |
 | Coburn, Thomas A. | (R-OK) | 2005-2015 |
 | Barrasso, John | (R-WY) | 2007- |
 | Paul, Rand | (R-KY) | 2011- |
 | Cassidy, Bill | (R-LA) | 2015- |
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Total: 52
* Studied medicine and law; practiced law.
** Studied medicine but did not practice.
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Key to Political Party Abbreviations
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Source: U.S., Congress, Senate, Biographical Directory of the United States Congress.
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