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FDA/Center for Food Safety and Applied Nutrition
USDA/Food Safety and Inspection Service
Centers for Disease Control and Prevention
September 2003
Quantitative Assessment of Relative Risk to Public Health
from Foodborne
Listeria monocytogenes
Among Selected Categories of Ready-to-Eat Foods
Table of Contents
Interpretive Summary
(
also available in
PDF
, 371 KB
)
Table of Contents (including
List of Tables and List of Figures
) (also available in
PDF
)
Summary of Public Comments and FDA/FSIS Revisions, Contributors, and Acknowledgements
(also available in
PDF
)
Executive Summary
(also available in
PDF
, 272 KB
)
Abbreviations, Acronyms, and Glossary
(also available in
PDF
)
I. Introduction
(also available in
PDF
)
II. Hazard Identification
(also available in
PDF
)
Listeriosis
Invasive Listeriosis
High Risk Individuals
Non-Invasive Listeriosis (Listerial Gastroenteritis)
Asymptomatic Carriage
Epidemiological Patterns of Listeriosis: Sporadic versus Outbreak-Associated Cases
Sporadic Listeriosis
Outbreak-Associated Listeriosis
III.Exposure Assessment
(also available in
PDF
, 293 KB
)
Food Category Identification
Food Consumption Data
Food Contamination Data
Growth Data
Modeling: Listeria monocytogenes Levels in Food at Retail
Results: Modeled Contamination at Retail
Modeling: Growth Between Retail and Consumption
Modeling: Interaction of Storage Times and Temperatures
Modeling: Thermal Inactivation
Results: Modeled Listeria monocytogenes Levels in Food at Consumption
IV.Hazard Characterization
(also available in
PDF
, 219 KB
)
Dose-Response Modeling
Comparison of the FDA/FSIS Revised Dose-Response Model to Other Dose-Response Models for
Listeria monocytogenes
Dose-Response in Animal Surrogates
Data Collected from Animal Studies
Modeling: Dose-Response in Mice
Dose-Response Curves for Infection and Serious Illness
Variability in Virulence
Host Susceptibility
Modeling: Host Susceptibility
Dose-Response Scaling Factor
Results: Dose-Response Curves for Three Population Groups
V.Risk Characterization
(also available in
PDF
, 514 KB
)
Simulation Modeling
Results
Overview and Discussion of Food Categories
Summaries of the Food Categories
VI.'What If' Scenarios
(also available in
PDF
)
VII.Interpretation and Conclusions
(also available in
PDF
)
References
(also available in
PDF
)
Apendices
Appendices 1-4 (also available in
PDF
, 260 KB
)
Appendix 1: Chronology of Technical and Scientific Reviews of the Revised FDA/FSIS
Listeria Monocytogenes
Risk Assessment Document
Appendix 2: Summary of Public Comments and FDA/FSIS's Responses
Appendix 3: An Overview of the Risk Assessment
Appendix 4: The Foodborne Diseases Active Surveillance Network
Appendix 5: Food Categories Modeled Distributions and Related Information
(also available in
PDF
, 315 KB
)
Appendix 6: Software
(also available in
PDF
)
Appendix 7:
Listeria
Contamination of Food Category Data Sets
(also available in
PDF
, 1,234 KB
)
Appendix 8: Growth of
Listeria Monocytogenes
in Foods
(also available in
PDF
)
Appendix 9: Using Outbreak Investigations in Quantitative Risk Assessment
(also available in
PDF
)
Appendix 10: Additional Risk Characterization Information
(also available in
PDF
)
Appendix 11: Research Needs
(also available in
PDF
)
Appendix 12: Cluster Analysis for Grouping of Food Categories
(also available in
PDF
)
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Hypertext updated by dvd 2003-DEC-23
